Pediatric Hydrocephalus
PI: Limbrick
Protocol ID: 201511126
Short study title: Advanced MR Imaging in Congenital Hydrocephalus
Short description: Washington University is a pioneer in developing advanced MR imaging techniques, which have helped to provide new insight into the brain’s structure and function. However, these techniques have rarely been used in pediatrics. Brain development and abnormalities associated with congenital diseases are largely unexplored in the setting of advanced MR imaging. The goal of this study is to use advanced MR imaging to better understand brain development in the setting of congenital hydrocephalus.
Key eligibility criteria:
- Any sex, age 17 years and younger
- Diagnosis of congenital hydrocephalus
- Patient scheduled to undergo surgery for hydrocephalus and a clinically indicated MRI before treatment
- Patients able to undergo two sessions of an MRI (30 minutes each). The first session will be either in the same setting as the clinically indicated pre-operative MRI or in a separate setting. The second will be after the surgery and before hospital discharge. Sedation will not be used in research-only MRIs.
Contact person: Diego Morales, 314-454-4688, d.morales@wustl.edu
Pediatric Oncology
PI: Limbrick
Protocol ID: 202002124
Short study title: Pediatric Neurosurgery Tissue Bank
Short description: The purpose of the Pediatric Neurosurgery Tissue Bank is to collect and store tissue samples from patients undergoing surgery. These samples include benign and malignant brain/spine tumors, normal/abnormal brain tissue, cerebrospinal fluid (CSF), bone, blood samples, and other related tissues. Specimens will be collected from the operating room or specialized procedure room in which said tissue is removed. Biological parents and siblings are also eligible to donate blood samples. Data from this tissue bank will be used to better understand disease progression, disease biology, generate realistic animal models of disease, and help to develop newer therapies.
Key eligibility criteria:
- Any sex, any age
- Patients scheduled to undergo surgical resection for brain/spinal tumor, seizure focus, or brain malformation
- Biological parents and siblings are also eligible to donate blood samples
- Patients at end-of-life are eligible to participate through the Legacy Brain Donation Program
Contact person: Diego Morales, 314-454-4688, d.morales@wustl.edu
Enrollment period: Current
Pediatric Epilepsy
PI: Limbrick
Protocol ID: 202002124
Short study title: MRI Predictors of Response to Vagal Nerve Stimulation
Short description: Patients with medically refractory epilepsy may be candidates for vagal nerve stimulation (VNS), which are implanted devices that alter the brain’s excitability and thereby decrease seizure frequency. However, it is not clear which patients will respond well to vagal nerve stimulation and will have an improved quality of life after surgery. The aim of this study is to analyze brain MRI scans for patients before and after surgery and to collect information relating to seizure frequency and quality of life in order to better identify patients who might benefit from this treatment.
Key eligibility criteria:
- Any sex, any age
- Patients undergoing VNS therapy
Contact person: Diego Morales, 314-454-4688, d.morales@wustl.edu
Enrollment period: Current