Alexander H. Stegh, PhD, professor of neurosurgery, vice chair of research in the Department of Neurosurgery and research director of the Brain Tumor Center, was recently inducted into the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows.
Election to AIMBE’s College of Fellows is limited to the top 2% of medical and biological engineers in these fields. Those elected are considered to have made outstanding contributions to engineering and medicine research, practice or education.
Stegh is a national leader in the study of glioblastoma, one of the most aggressive forms of brain cancer. His research focuses on uncovering genetic drivers of glioblastoma through a combination of cellular and molecular biology, engineered mouse models, and oncogenomics, the latter of which is a subfield of genomics that characterizes cancer-associated genes.
Additionally, Stegh’s research is noted for pioneering efforts to develop nanotechnologies to dial down the expression of oncogenes and activate anti-tumor immune responses. His success in translating nanoparticle-based precision medicine approaches to brain cancer patients has led to a clinical trial in people involving gene-regulatory spherical nucleic acids (SNAs) for the treatment of recurrent glioblastoma.