Brenton Pennicooke, MD, MS, FAANS

Brenton Pennicooke, MD, MS, FAANS

Assistant Professor of Neurosurgery and Orthopedic Surgery and Biomedical Engineering


  • Minimally Invasive Spinal Surgery
  • Spinal Deformity (Cervical or Thoracolumbar)
  • Spinal Tumors/Spinal Oncology
  • Artificial Disc Replacement
  • Spinal Stenosis
  • Degenerative Spine Disease
  • Spinal Trauma

Call 636-916-7140 for Patient Appointments

I am committed to providing exceptional care tailored to each patient to achieve optimal outcomes and improvements in quality-of-life.”

Dr. Pennicooke


BA, Biology with Departmental Honors
The Johns Hopkins University
Baltimore, MD

MS, Molecular and Cellular Biology
The Johns Hopkins University
Baltimore, MD

MD, Harvard Medical School
Boston, MA


Resident, New York-Presbyterian Hospital/Weill Cornell Medical Center & Memorial Sloan Kettering Cancer Center
Departments of Neurosurgery
New York, NY
2012 – 2019


Spine Research Fellow
New York-Presbyterian Hospital/Weill Cornell Medical Center & Cornell University
Departments of Neurological Surgery & Biomedical Engineering
New York, NY & Ithaca, NY
2015 – 2016

Predictive Analytics/Machine Learning Research Fellow
New York-Presbyterian Hospital/Weill Cornell Medical Center & Cornell Tech
Departments of Neurological Surgery & Operations Research and Information Engineering
New York, NY
2018 – 2019

Clinical Instructor & Complex Spinal Reconstruction and Minimally Invasive Spine Surgery Clinical Fellow
Department of Neurological Surgery
University of California-San Francisco
San Francisco, CA
2019 –2020

Research focus

Dr. Pennicooke is a spine fellowship-trained neurosurgeon who completed a post-residency fellowship in complex spinal reconstruction and minimally invasive spine surgery under the guidance of both neurosurgeons and orthopedic spine surgeons. His diverse training gives him a unique insight into treating a wide range of spinal diseases from significant spinal deformity/malalignment to herniated discs. Dr. Pennicooke is an expert in utilizing artificial intelligence, advanced machine learning, and causal inference to analyze patient-outcome data. His research endeavors to extensively understand the nuances of spinal disease, develop personalized patient treatment regimens, and build novel clinical support tools.

Honors & leadership roles

  • Washington University School of Medicine Faculty Diversity Scholar
  • Chairman of Housestaff Quality Council, New York-Presbyterian Hospital-Weill Cornell Medical Center
  • Best Oral Presentation at World Forum for Spine Research Award
  • Weill Cornell Dept of Neurosurgery Michael Apuzzo Outstanding Research Writing Award
  • Joint Spine Section Charlie Kuntz Scholar Award
  • Weill Cornell Dept of Neurosurgery Bronson Ray Resident Research Day Award
  • AO Spine Foundation Spine Fellowship Best Posters Distinction
  • Johns Hopkins University Diversity Leadership Award
  • Johns Hopkins University Dean of Student Life Achievement Award
  • Office of Multicultural Student Affairs Director’s Award

Board certification

American Board of Neurological Surgery Certified (2023)

Hospital appointments

Barnes-Jewish St. Peters Hospital