Matthew D. Smyth, MD, FACS, FAAP

Appoline Blair Professor of Pediatric Neurosurgery
Professor of Neurological Surgery and Pediatrics
Co-Director, Washington University Pediatric Epilepsy Center at St. Louis Children’s Hospital
Director, St. Louis Children's Hospital Pediatric Neurosurgery Fellowship


  • Epilepsy surgery
  • Craniofacial surgery
  • Minimally invasive endoscopic cranial surgery
  • Minimally invasive laser ablation surgery
  • Robotic-assisted neurosurgery
  • Radiosurgery

Call 314-454-2810 for Pediatric Appointments

Our team’s pioneering advances in less invasive neurosurgical procedures are enhancing safety, comfort and outcomes for our patients every day.

Dr. Matthew D. Smyth


BA, Neurobiology and Behavior, Cornell University 
Ithaca, NY

MD, University of California, San Francisco 
School of Medicine
San Francisco, California


Intern, General Surgery 
University of California, Irvine
School of Medicine
Irvine, California
1996 – 1997

Resident, Neurological Surgery 
University of California, Irvine
School of Medicine
Irvine, California 

Resident, Neurological Surgery
University of California, San Francisco
School of Medicine
San Francisco, California
1997 – 2002


Fellow, Pediatric Neurosurgery
Children’s Hospital, University of Alabama at Birmingham
Birmingham, Alabama
2002 – 2003

Research focus

Focal cortical cooling for epilepsy, cortical dysplasia, advanced brain imaging, brain stimulation for epilepsy, epilepsy surgery clinical outcomes, craniofacial surgery clinical outcomes. 

View research, publications and collaborations »

Honors & leadership roles

  • Editorial Board, Journal of Neurosurgery: Peditarics
  • Secretary, AANS/CNS Joint Section on Pediatric Neurological Surgery
  • Secretary, Neurosurgical Society of America
  • St. Louis Children’s Hospital Neurosciene Unit-Based Joint Practice Team Physician Leader
  • Director, St. Louis Children’s Hospital Pediatric Neurosurgery Fellowship
  • Director, Pediatric Epilepsy Center at Washington University
  • Director, Pediatric Epilepsy Advanced Technologies Clinic
  • Washington University Distinguished Clinical Faculty Award 2020
  • Washington University Department of Neurosurgery Faculty Teaching Award 2017

Board certification

American Board of Neurological Surgery (2005, recertified 2015)
American Board of Pediatric Neurological Surgeons (2006, recertified 2016)

Hospital appointments

St. Louis Children’s Hospital
Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
Mercy Hospital, Consulting Staff