As one of the top recipients of National Institutes of Health (NIH) funding in the US, our department is advancing the understanding and treatment of neurological conditions. Our faculty members encourage and welcome collaborations and regularly publish their research to share findings with others also seeking to advance human healthcare.

Publications 2019-2021

Brain Tumor

Immune profiling of pituitary tumors reveals variations in immune infiltration and checkpoint molecule expression. 

Mei Y, Bi WL, Agolia J, Hu C, Giantini Larsen AM, Meredith DM, Al Abdulmohsen S, Bale T, Dunn GP, Abedalthagafi M, Dunn IF.

Pituitary. Jan. 25, 2021.

Proteogenomic and metabolomic characterization of human glioblastoma.

Wang LB, Karpova A, Gritsenko MA, Kyle JE, Cao S, Li Y, Rykunov D, Colaprico A, Rothstein JH, Hong R, Stathias V, Cornwell M, Petralia F, Wu Y, Reva B, Krug K, Pugliese P, Kawaler E, Olsen LK, Liang WW, Song X, Dou Y, Wendl MC, Caravan W, Liu W, Cui Zhou D, Ji J, Tsai CF, Petyuk VA, Moon J, Ma W, Chu RK, Weitz KK, Moore RJ, Monroe ME, Zhao R, Yang X, Yoo S, Krek A, Demopoulos A, Zhu H, Wyczalkowski MA, McMichael JF, Henderson BL, Lindgren CM, Boekweg H, Lu S, Baral J, Yao L, Stratton KG, Bramer LM, Zink E, Couvillion SP, Bloodsworth KJ, Satpathy S, Sieh W, Boca SM, Schürer S, Chen F, Wiznerowicz M, Ketchum KA, Boja ES, Kinsinger CR, Robles AI, Hiltke T, Thiagarajan M, Nesvizhskii AI, Zhang B, Mani DR, Ceccarelli M, Chen XS, Cottingham SL, Li QK, Kim AH, Fenyö D, Ruggles KV, Rodriguez H, Mesri M, Payne SH, Resnick AC, Wang P, Smith RD, Iavarone A, Chheda MG, Barnholtz-Sloan JS, Rodland KD, Liu T, Ding L; Clinical Proteomic Tumor Analysis Consortium.

Cancer Cell. Feb. 11, 2021.

Commentary: Adjuvant Radiotherapy vs Watchful Waiting for World Health Organization Grade II Atypical Meningioma: A Single-Institution Experience.

Chicoine MR, Kim AH.

Neurosurgery. Feb. 20, 2021.

Defining phenotypic and functional heterogeneity of glioblastoma stem cells by mass cytometry.

Galdieri L, Jash A, Malkova O, Mao DD, DeSouza P, Chu YE, Salter A, Campian JL, Naegle KM, Brennan CW, Wakimoto H, Oh ST, Kim AH, Chheda MG.

JCI Insight. Feb. 22, 2021.

Internal dose escalation associated with increased local control for melanoma brain metastases treated with stereotactic radiosurgery.

Kennedy WR, DeWees TA, Acharya S, Mahmood M, Knutson NC, Goddu SM, Kavanaugh JA, Mitchell TJ, Rich KM, Kim AH, Leuthardt EC, Dowling JL, Dunn GP, Chicoine MR, Perkins SM, Huang J, Tsien CI, Robinson CG, Abraham CD.

Journal of Neurosurgery. Dec. 11, 2020.

Using Histopathology to Assess the Reliability of Intraoperative Magnetic Resonance Imaging in Guiding Additional Brain Tumor Resection: A Multicenter Study.

Shah AS, Yahanda AT, Sylvester PT, Evans J, Dunn GP, Jensen RL, Honeycutt J, Cahill DP, Sutherland GR, Oswood M, Shah M, Abram SR, Rich KM, Dowling JL, Leuthardt EC, Dacey RG, Kim AH, Zipfel GJ, Limbrick DD, Smyth MD, Leonard J, Chicoine MR.

Neurosurgery. Dec. 15, 2020.

A feasibility study to evaluate early treatment response of brain metastases one week after stereotactic radiosurgery using perfusion weighted imaging. 

Huang J, Milchenko M, Rao YJ, LaMontagne P, Abraham C, Robinson CG, Huang Y, Shimony JS, Rich KM, Benzinger T.

PLoS One. Nov. 13, 2020.

Impact of Intraoperative Magnetic Resonance Imaging and Other Factors on Surgical Outcomes for Newly Diagnosed Grade II Astrocytomas and Oligodendrogliomas: A Multicenter Study.

Yahanda AT, Patel B, Shah AS, Cahill DP, Sutherland G, Honeycutt J, Jensen RL, Rich KM, Dowling JL, Limbrick DD, Dacey RG, Kim AH, Leuthardt EC, Dunn GP, Zipfel GJ, Leonard JR, Smyth MD, Shah MV, Abram SR, Evans J, Chicoine MR.

Neurosurgery. Dec. 15, 2020.

Emerging immunotherapies for malignant glioma: from immunogenomics to cell therapy.

Dunn GP, Cloughesy TF, Maus MV, Prins RM, Reardon DA, Sonabend AM.

Neuro-Oncology. Oct. 14, 2020.

Treatment of an aggressive orthotopic murine glioblastoma model with combination checkpoint blockade and a multivalent neoantigen vaccine.

Liu CJ, Schaettler M, Blaha DT, Bowman-Kirigin JA, Kobayashi DK, Livingstone AJ, Bender D, Miller CA, Kranz DM, Johanns TM, Dunn GP.

Neuro-Oncology. Sep. 29, 2020.

Prognostic impact of CDKN2A/B deletion, TERT mutation, and EGFR amplification on histological and molecular IDH-wildtype glioblastoma. 

Ma S, Rudra S, Campian JL, Dahiya S, Dunn GP, Johanns T, Goldstein M, Kim AH, Huang J.

Neuro-oncology Advances. Sept. 18, 2020

Functional connectivity within glioblastoma impacts overall survival.

Daniel AGS, Park KY, Roland JL, Dierker D, Gross J, Humphries JB, Hacker CD, Snyder AZ, Shimony JS, Leuthardt EC.

Neuro-Oncology. Aug. 13, 2020.

Axis-specific analysis and predictors of endocrine recovery and deficits for non-functioning pituitary adenomas undergoing endoscopic transsphenoidal surgery.

Hwang JY, Aum DJ, Chicoine MR, Dacey RG Jr, Osbun JW, Rich KM, Zipfel GJ, Klatt-Cromwell CN, McJunkin JL, Pipkorn P, Schneider JS, Silverstein JM, Kim AH.

Pituitary. Aug. 2020.

Impact of Intraoperative Magnetic Resonance Imaging and Other Factors on Surgical Outcomes for Newly Diagnosed Grade II Astrocytomas and Oligodendrogliomas: A Multicenter Study.

Yahanda AT, Patel B, Shah AS, Cahill DP, Sutherland G, Honeycutt J, Jensen RL, Rich KM, Dowling JL, Limbrick DD, Dacey RG, Kim AH, Leuthardt EC, Dunn GP, Zipfel GJ, Leonard JR, Smyth MD, Shah MV, Abram SR, Evans J, Chicoine MR.

Neurosurgery. July 27, 2020.

Therapeutic enhancement of blood-brain and blood-tumor barriers permeability by laser interstitial thermal therapy.

Salehi A, Paturu MR, Patel B, Cain MD, Mahlokozera T, Yang AB, Lin TH, Leuthardt EC, Yano H, Song SK, Klein RS, Schmidt R, Kim AH.

Neuro-Oncology Advances. June 30, 2020.

Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model.

Pacia CP, Zhu L, Yang Y, Yue Y, Nazeri A, Michael Gach H, Talcott MR, Leuthardt EC, Chen H.

Scientific Reports. May 4, 2020.

Staged Laser Interstitial Thermal Therapy (LITT) Treatments to Left Insular Low-Grade Glioma.

Hafez DM, Liekweg C, Leuthardt EC.

Neurosurgery. March 1, 2020.

Laser Interstitial Thermal Therapy. 

Patel B, Kim AH.

Missouri Medicine. Jan-Feb. 2020.

Therapeutic Role of Gamma Knife Stereotactic Radiosurgery in Neuro-Oncology.

Desai R, Rich KM.

Missouri Medicine, Jan-Feb. 2020.

Image Guidance in Cranial Neurosurgery: How a Six-Ton Magnet and Fluorescent Colors Make Brain Tumor Surgery Better. 

Chicoine MR, Sylvester P, Yahanda AT, Shah A.

Missouri Medicine, Jan-Feb. 2020.

An Innovative Immunotherapy Vaccine with Combination Checkpoint Blockade as a First Line Treatment for Glioblastoma in the Context of Current Treatments. 

Coxon AT, Johanns TM, Dunn GP.

Missouri Medicine, Jan-Feb. 2020.

Functional

Resting State Functional MR Imaging of Language Function. 

Lee JJ, Luckett P, Fakhri MM, Leuthardt EC, Shimony JS.

Neuroimaging Clinics of North America. Feb. 2021.

Mapping language function with task-based vs. resting-state functional MRI.

Park KY, Lee JJ, Dierker D, Marple LM, Hacker CD, Roland JL, Marcus DS, Milchenko M, Miller-Thomas MM, Benzinger TL, Shimony JS, Snyder AZ, Leuthardt EC.

PLOS One. July 31, 2020.

Case Series: Unilateral Amygdala Ablation Ameliorates Post-Traumatic Stress Disorder Symptoms and Biomarkers (COVER ARTICLE)

Kelly R Bijanki, PhD,  Sanne J H van Rooij, PhD,  Timothy D Ely, PhD,  Jennifer S Stevens, PhD, Cory S Inman, PhD,  Rebecca E Fasano, MD,  Sierra E Carter, PhD,  Sterling J Winters, BS, Justin R Baman, BS,  Daniel L Drane, PhD.

Neurosurgery, Oct. 2020

Neurotechnology

A Review of Passive Brain Mapping Techniques in Neurological Surgery. 

Roland JL, Hacker CD, Leuthardt EC.

Neurosurgery. Nov. 23, 2020.

Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion. 

Koo J, Kim SB, Choi YS, Xie Z, Bandodkar AJ, Khalifeh J, Yan Y, Kim H, Pezhouh MK, Doty K, Lee G, Chen YY, Lee SM, D’Andrea D, Jung K, Lee K, Li K, Jo S, Wang H, Kim JH, Kim J, Choi SG, Jang WJ, Oh YS, Park I, Kwak SS, Park JH, Hong D, Feng X, Lee CH, Banks A, Leal C, Lee HM, Huang Y, Franz CK, Ray WZ, MacEwan M, Kang SK, Rogers JA.

Science Advances. Aug. 28, 2020.

Pediatrics

The Role of SPECT and PET in Epilepsy

Ponisio MR, Zempel JM, Day BK, Eisenman LN, Miller-Thomas MM, Smyth MD, Hogan RE.

AJR American Journal of Roentgenology. March 2021.

Rare and de novo coding variants in chromodomain genes in Chiari I malformation.

Sadler B, Wilborn J, Antunes L, Kuensting T, Hale AT, Gannon SR, McCall K, Cruchaga C, Harms M, Voisin N, Reymond A, Cappuccio G, Brunetti-Pierri N, Tartaglia M, Niceta M, Leoni C, Zampino G, Ashley-Koch A, Urbizu A, Garrett ME, Soldano K, Macaya A, Conrad D, Strahle J, Dobbs MB, Turner TN, Shannon CN, Brockmeyer D, Limbrick DD, Gurnett CA, Haller G.

The American Journal of  Human Genetics. Jan. 7, 2021.

Commentary: Tract-Specific Relationships Between Cerebrospinal Fluid Biomarkers and Periventricular White Matter in Posthemorrhagic Hydrocephalus of Prematurity.

Warsi NM, Ibrahim GM.

Neurosurgery. Dec. 28, 2020.

Use of fast-sequence spine MRI in pediatric patients

Gewirtz JI, Skidmore A, Smyth MD, Limbrick DD, Goyal M, Shimony JS, McKinstry RC, Groves ML, Strahle JM.

Journal of Neurosurgery: Pediatrics. Sept. 18, 2020.

Feasibility and safety of transradial access for pediatric neurointerventions. 

Srinivasan VM, Hadley CC, Prablek M, LoPresti M, Chen SH, Peterson EC, Sweid A, Jabbour P, Young C, Levitt M, Osbun JW, Burkhardt JK, Johnson J, Kan P.

Journal of Neurointerventional Surgery. Sept. 2020.

School-Aged Anthropometric Outcomes After Endoscopic or Open Repair of Metopic Synostosis

Ha AY, Skolnick GB, Chi D, Nguyen DC, Naidoo SD, Smyth MD, Patel KB.

Pediatrics. September 2020.

Selective Dorsal Rhizotomy for the Treatment of Spastic Hemiplegic Cerebral Palsy.

Park TS, Joh S, Walter DM, Meyer NL, Dobbs MB.

Cureus. Aug. 7, 2020.

Preterm intraventricular hemorrhage in vitro: modeling the cytopathology of the ventricular zone.

Castaneyra-Ruiz L, McAllister JP 2nd, Morales DM, Brody SL, Isaacs AM, Limbrick DD Jr. 

Fluids Barriers of the CNS. July 20, 2020.

Intraventricular Hemorrhage Clearance in Human Neonatal Cerebrospinal Fluid: Associations With Hydrocephalus.

Mahaney KB, Buddhala C, Paturu M, Morales D, Limbrick DD Jr, Strahle JM.

Stroke. June 2020.

Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.

Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD Jr, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT.

Nature Reviews Neurology. May, 2020.

In support of selective dorsal rhizotomy in cerebral palsy: the strength of clinical experience.

Park TS.

Developmental Medicine and Child Neurology. May 2020.

Radiological and clinical associations with scoliosis outcomes after posterior fossa decompression in patients with Chiari malformation and syrinx from the Park-Reeves Syringomyelia Research Consortium.

Strahle JM, Taiwo R, Averill C, Torner J, Gewirtz JI, Shannon CN, Bonfield CM, Tuite GF, Bethel-Anderson T, Anderson RCE, Kelly MP, Shimony JS, Dacey RG, Smyth MD, Park TS, Limbrick DD; Park-Reeves Syringomyelia Research Consortium.

Journal of Neurosurgery: Pediatrics. April 10, 2020.

Cost comparison of surgical management of nonsagittal synostosis: traditional open versus endoscope-assisted techniques. 

Zubovic E, Lapidus JB, Skolnick GB, Naidoo SD, Smyth MD, Patel KB.

Journal of Neurosurgery: Pediatrics. Jan. 10, 2020.

Corpus callosotomy performed with laser interstitial thermal therapy

Roland JL, Akbari SHA, Salehi A, Smyth MD.

Journal of Neurosurgery. Dec. 13, 2019.

Peripheral Nerve

Analysis of the effect of intraoperative neuromonitoring during resection of benign nerve sheath tumors on gross-total resection and neurological complications.

Wilson TJ, Hamrick F, Alzahrani S, Dibble CF, Koduri S, Pendleton C, Saleh S, Ali ZS, Mahan MA, Midha R, Ray WZ, Yang LJS, Zager EL, Spinner RJ.

Journal of Neurosurgery. Feb. 12, 2021.

A qualitative study of life satisfaction after surgery for adult traumatic brachial plexus injury.

Dy CJ, Brogan DM, Rolf L, Ray WZ, Wolfe SW, James AS.

Bone and Joint Open. Jan. 3, 2021.

Variability in Surgeon Approaches to Emotional Recovery and Expectation Setting After Adult Traumatic Brachial Plexus Injury.

Dy CJ, Brogan DM, Rolf L, Ray WZ, Wolfe SW, James AS.

Official Journal of The American Society for Surgery of the Hand. Jan. 1, 2021.

Incidence of Surgically Treated Brachial Plexus Injury in Privately Insured Adults Under 65 Years of Age in the USA.

Dy CJ, Peacock K, Olsen MA, Ray WZ, Brogan DM.

HSS Journal. Dec. 1, 2020.

Social Support and Coping Strategies in Patients with Traumatic Brachial Plexus Injury.

Sachar R, Landau AJ, Ray WZ, Brogan DM, Dy CJ.

HSS Journal. Dec. 1, 2020.

Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration.

Choi YS, Hsueh YY, Koo J, Yang Q, Avila R, Hu B, Xie Z, Lee G, Ning Z, Liu C, Xu Y, Lee YJ, Zhao W, Fang J, Deng Y, Lee SM, Vázquez-Guardado A, Stepien I, Yan Y, Song JW, Haney C, Oh YS, Liu W, Yoon HJ, Banks A, MacEwan MR, Ameer GA, Ray WZ, Huang Y, Xie T, Franz CK, Li S, Rogers JA.

Nature Communications. Nov. 25, 2020.

Spine

Augmented reality-mediated stereotactic navigation for execution of en bloc lumbar spondylectomy osteotomies.

Molina CA, Dibble CF, Lo SL, Witham T, Sciubba DM.

Journal of Neurosurgery: Spine. March 5, 2021.

Multi-modal biomarkers of low back pain: A machine learning approach.

Lamichhane B, Jayasekera D, Jakes R, Glasser MF, Zhang J, Yang C, Grimes D, Frank TL, Ray WZ, Leuthardt EC, Hawasli AH. 

NeuroImage: Clinical. Dec. 8, 2020.

Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration. 

Choi YS, Hsueh YY, Koo J, Yang Q, Avila R, Hu B, Xie Z, Lee G, Ning Z, Liu C, Xu Y, Lee YJ, Zhao W, Fang J, Deng Y, Lee SM, Vázquez-Guardado A, Stepien I, Yan Y, Song JW, Haney C, Oh YS, Liu W, Yun HJ, Banks A, MacEwan MR, Ameer GA, Ray WZ, Huang Y, Xie T, Franz CK, Li S, Rogers JA.

Nature Communications. Nov. 25, 2020.

A cadaveric precision and accuracy analysis of augmented reality-mediated percutaneous pedicle implant insertion.

Molina CA, Phillips FM, Colman MW, Ray WZ, Khan M, Orru’ E, Poelstra K, Khoo L.

Journal of Neurosurgery: Spine. Oct. 30, 2020.

Project management for developing a spine “enhanced recovery after surgery” program in a large university-affiliated hospital.

Hawasli AH, Ray WZ, Goad MA, Frank TL, Ellis ER, Schmidt M, Lamartina PJ.

Neurosurgical Sciences. April 2020.

Advances in Techniques and Technology in Minimally Invasive Lumbar Interbody Spinal Fusion.

Jain D, Ray WZ, Vaccaro AR.

JB & JS Reviews. April 2020.

Noninvasive Quantification of Axonal Loss in the Presence of Tissue Swelling in Traumatic Spinal Cord Injury Mice. 

Lin TH, Sun P, Hallman M, Hwang FC, Wallendorf M, Ray WZ, Spees WM, Song SK.

Journal of Neurotrauma. Aug. 1, 2019

Vascular

Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage. 

Athiraman U, Liu M, Jayaraman K, Yuan J, Mehla J, Zipfel GJ.

Brain Research. Jan. 1, 2021.

Unique challenges for glioblastoma immunotherapy – Discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. 

Chuntova P, Chow F, Watchmaker P, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown C, Chen Y, Fecci P, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H.

Society for NeuroOncology. Dec. 24, 2020.

Anesthetic Conditioning for Secondary Brain Injury After Aneurysmal Subarachnoid Hemorrhage.

Athiraman U, Zipfel GJ.

World Neurosurgery. Nov. 2020.

SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage.

Vellimana AK, Aum DJ, Diwan D, Clarke JV, Nelson JW, Lawrence M, Han BH, Gidday JM, Zipfel GJ.

Experimental Neurology. Oct. 1, 2020.

Microvascular platelet aggregation and thrombosis after subarachnoid hemorrhage: A review and synthesis.

Clarke JV, Suggs JM, Diwan D, Lee JV, Lipsey K, Vellimana AK, Zipfel GJ.

Journal of Cerebral Blood Flow & Metabolism. Aug. 2020.

Transradial intraoperative cerebral angiography: a multicenter case series and technical report.

Osbun JW, Patel B, Levitt MR, Yahanda AT, Shah A, Dlouhy KM, Thatcher JP, Chicoine MR, Kim LJ, Zipfel GJ.

Journal of NeuroInterventional Surgery. Feb. 2020.